Pharmacology & Toxicology Faculty
Anne McLaren Dorrance, Associate Professor
1993, B.Sc. Biological Sciences University of Edinburgh                      
1997, Ph.D University of Glasgow                                           
1996-97, Research Assistant, Department of Medicine and Therapeutics, Western Infirmary, University of Glasgow, Glasgow, Scotland.
2001, Research Scientist, Department of Physiology, The Medical College of Georgia, Augusta, Ga.
2001-2007, Assistant Professor, Department of Physiology, The Medical College of Georgia, Augusta, Ga.
2007- Presemt, Associate Professor, Pharmacology & Toxicology, Michigan State University
   Contact Info:dorranc3@msu.edu Phone: (517) 432-7403 Fax: (517) 353-8915

Postdoctoral Training
July 1997-June 1999: Postdoctoral Fellow, Department of Internal Medicine, The University of Michigan, Ann Arbor, MI.
uly 1999-Dec 1999: Postdoctoral Fellow, Department of Physiology, The University of Michigan, Ann Arbor, MI.
Jan 2000-Dec 2000: Postdoctoral Fellow, Department of Physiology, The Medical College of Georgia, Augusta, GA.

Awards
1991: Wellcome Trust Vacation Scholarship
1992: The Nuffield Foundation Undergraduate Bursary
1993: Chest, Heart and Stroke Vacation Scholarship
1999: Hall Fellowship; European Society for Hypertension, Young Investigators Award
2000: The Caroline tum Suden/Frances A. Hellebrant Professional Opportunity Award; Searle Young Investigator Award at the 26th International Aldosterone Conference; Poster presentation award for the University System of Georgia Research Symposium; International Society for Hypertension Young Investigators Award
2002: Hamilton Fellow, The Medical College of Georgia

2004: Fellow of the American Heart Association, Council for High Blood Pressure Research
2008: Established Investigator Award, American Heart Association

Editorial Duties

Ad Hoc reviewer for: Hypertension, The American Journal of Hypertension, The American Journal of Physiology (Endocrinology and Metabolism and Regulatory, Integrative and Comparative Physiology), The European Journal of Pharmacology, Circulation, Vascular Pharmacology, Clinical Science, Journal of Hypertension, Neuropharmacology and Journal of Neuroscience Methods.

2003-2006 Editorial board of Endocrinology
2006-Present Editorial board of Stroke

Publications within the last five years

B.M. Mitchell, A.M. Dorrance, R.C. Webb, GTP cyclohydrolase 1 down regulation contributes to glucocorticoid hypertension in rats. Hypertension 41: 669-674, 2003.

B.M. Mitchell, A.M. Dorrance, R.C. Webb, GTP cyclohydrolase 1 inhibition attenuates vasodilation and increases blood pressure in rats. American Journal of Physiology, 285: H2165-H2170, 2003.

M-H Wang, A. Smith, Y Zhou, H-H- Cang, S.B. Lin, X Zhou, J.D. Imig, A.M. Dorrance Down regulation of renal CYP-derived eicosanoid synthesis in rats with diet induced hypertension. Hypertension. 42: 594 – 599, 2003.

B.M. Mitchell, A.M. Dorrance, E.A. Mack, R.C. Webb, Glucocorticoids Decrease GTP cyclohydrolase and tetrahydrobiopterin-dependent vasorelaxation through glucocorticoid receptors. Journal of Cardiovascular Pharmacology, 43:8-13, 2004

B.M. Mitchell, A.M. Dorrance, A. Ergul, R.C. Webb Sepiapterin decreases vasorelaxation in NOS-inhibition –induced hypertension. Journal of Cardiovascular Pharmacology, 43:93-98, 2004.

S.H. Mehta, R.C. Webb, A. Ergul, A. Tawfik, A. M. Dorrance, Neuroprotection by tempol in a model of iron-induced oxidative stress in acute ischemic stroke. American Journal Of Physiology, 286, R283-288, 2004.

D.P. Slovut, S.H.Mehta, A.M. Dorrance, F.C. Brosius, S.W. Watts, R.C. Webb, Increased Vascular Sensitivity and Connexin43 Expression After Sympathetic Denervation. Cardiovascular Research 62:388-96, 2004.

BM Mitchell, AM, Dorrance RC. Webb Phenylalanine improves dilation and blood pressure in GTP cyclohydrolase inhibition-induced hypertensive rats. J Cardiovascular Pharmacology, 43(6):758-63, 2004.

Z. Ying, L. Jin, A.M. Dorrance, R.C. Webb, Increased expression of mRNA for regulator of G protein signaling domain containing Rho Guanine nucleotide exchange factors in aorta from stroke-prone spontaneously hypertensive rats. American Journal of Hypertension, 17: 981-5, 2004.

Y. Zhou, S. Lin, H-H. Chang, C. J. Du, Z. Dong, A.M. Dorrance, M.W. Brands, M.H. Wang, Gender differences of renal CYP-derived eicosanoid synthesis in rats fed a high fat diet. American Journal of Hypertension 18: 530-7. 2005.
A.K. Harris, J.R. Hutchinson, K. Sachindanandam, A. Dorrance, D. Stepp, S.C. Fagan, A. Ergul. Type 2 diabetes causes remodeling of cerebrovasculature via differential regulation of matrix metalloproteinases and collagen synthesis: role of endothelin-1. Diabetes 54: 2638-2644, 2005.

A.M. Dorrance, N.Rupp, D.M. Pollock, J.W. Newman, B.D. Hammock, J.D. Imig, Soluble epoxide hydrolase inhibition reduces ischemic cerebral infarct size in stroke-prone spontaneously hypertensive rats. Journal of Cardiovascular Pharmacology 46: 842-848, 2005.

A.D. Smith, M.W. Brands, M-H. Wang, A.M, Dorrance. Obesity-induced hypertension develops in young rats independently of the renin-angiotensin aldosterone system. Experimental Biology and Medicine, 231: 282-287,2006.

A.M. Dorrance, N.C. Rupp, E.F. Nogueira.Mineralocorticoid Receptor Activation Causes Cerebral Vessel Remodeling And Exacerbates The Damage Caused By Cerebral Ischemia. Hypertension, 47[Part 2]: 590-595, 2006.

A.D. Smith, A.M. Dorrance, Arachidonic Acid Induces Augmented Vasoconstriction Via Cyclooxygenase 1in The Aorta From Rats Fed A High Fat Diet. Prostaglandins Leukotrienes and Essential Fatty Acids, 75: 43-49, 2006.

T.E. Scheetz, K.Y. Kim, R.E. Swiderski, A.R. Philp, T.A. Braun, K.L. Knudtson, A.M. Dorrance, G.F, DiBona, J. Huang, T.L. Casavant, V.C. Sheffield, E.M. Stone. Regulation of gene expression in the mammalian eye and its relevance to eye disease. Proceedings of the National Academy of Science USA. 103(39): 14429-14434, 2006.

A.M. Dorrance, D.M. Pollock, O.P. Romanko, D.W. Stepp, A High Potassium Diet Reduces Infarct Size and Improves Vascular Structure in Hypertensive Rats. American Journal of Physiology, 292: R415-R422, 2007.

C.S. Rigsby, D.M. Pollock, A.M. Dorrance, Spironolactone Improves Vascular Structure and Increases Tone in the Cerebral Vasculature of Hypertensive Rats. Microvascular Research, 73:198-205, 2007.

A.M. Dorrance, Interleukin 1-Beta (IL-1b) Enhances Contractile Responses In Aorta From Hypertensive, But Not Normotensive, Rats. Vascular Pharmacology. 47:160-165, 2007.

C.S. Rigsby, D.M. Pollock, A.M. Dorrance, Sexual Dimorphism in the Actions of Mineralocorticoid Receptor Antagonists in Stroke-Prone Hypertensive Rats: An Effect of Receptor Expression. American Journal of Physiology, 293: R1754-63, 2007.

C.S. Rigsby, D.M. Pollock, A.M. Dorrance, Dietary Potassium Supplementation Improves Vascular Structure and Ameliorates the Damage Caused by Cerebral Ischemia In Normotensive Rats. Nutrition & Metabolism 2008, 5:3.

J.M. Osmond, C.S. Rigsby, A.M. Dorrance, Is the Mineralocorticoid Receptor a Potential Target for Stroke Prevention? Clinical Science, 114: 37-47, 2008.

A.M. Dorrance, Stroke Therapy: Is Spironolactone the Holy Grail? In Press, Endocrinology.