Jane F. Maddox, Assistant Professor
1978-82 B.S., Veterinary Science, Michigan State University
1982-84 D.V.M., Veterinary Medicine, Michigan State University
1984-86 Private Veterinary Practice, large and small animal
1987-93 Ph.D., Pathobiology, The Pennsylvania State University
1992-95 Postdoctoral Fellow, Brigham and Women’s Hospital, Harvard University
1995-97 Instructor, Brigham and Women’s Hospital, Harvard University
1997-00 Research Associate, The Pennsylvania State University
2000-present Assistant Professor, Pharmacology & Toxicology, Michigan State University
Arthritis Investigator Award, Arthritis Foundation – Role of lipoxins in endothelial cell/leukocyte-mediated chronic inflammation during selenium deficiency (Hulda Irene Duggan Award, 8/98-7/04).
R03: NIH (NIAAA, NCCAM and ODS): SAMe Inhibits Inflammatory-mediated Increase in Toxicity; Principal Investigator, 2002-2004.
Selected Publications Since 2001
Weaver JA, Maddox JF, Cao YZ, Mullarky IK, Sordillo LM: Increased 15-HPETE production decreases prostacyclin synthase activity during oxidant stress in aortic endothelial cells. Free Radic. Biol. Med. 30(3): 299-308, 2001.
Maddox JF, Roth RA, Ganey PE: Allyl alcohol activation of protein kinase Cd leads to cytotoxicity of rat hepatocytes. Chem. Res. Toxicol. 16(5): 609-615, 2003.
Roth RA, Luyendyk JP, Maddox JM, Ganey PE: Inflammation and drug idiosyncrasy—Is there a connection? J. Pharmacol. Exp. Ther. 307(1): 1-8, 2003.
Luyendyk JP, Maddox JF, Cosma GN, Ganey PE, Cockerell GL, Roth RA: Ranitidine treatment during a modest inflammatory response precipitates idiosyncrasy-like liver injury in rats. J. Pharmacol. Exp. Ther. 307(1): 9-16, 2003.
Copple BL, Rondelli CM, Maddox JF, Hoglen NS, Ganey PE, Roth RA: Modes of cell death in rat liver after monocrotaline exposure. Toxicol. Sci. 77(1): 172-182, 2004.
Harrigan GG, LaPlante RH, Cosma GN, Cockerell G, Goodacre R, Maddox JF, Luyendyk JP, Ganey PE, Roth RA: Application of high-throughput Fourier-transform infrared spectroscopy in toxicology studies: Contribution to a study on the development of an animal model for idiosyncratic toxicity. Toxicol. Lett. 146(3): 197-205, 2004.
Maddox JF, Domzalski AC, Roth RA, Ganey PE: 15-Deoxy prostaglandin J2 enhances ally alcohol-induced toxicity in rat hepatocytes. Toxicol. Sci. 77(2): 290-298, 2004.
Luyendyk JP, Mattes WB, Burgoon LD, Zacharewski TR, Maddox JF, Cosma GN, Ganey PE, Roth RA: Gene expression analysis points to hemostasis in livers of rats cotreated with lipopolysaccharide and ranitidine. Toxicol. Sci. 80(1): 203-213, 2004.
Ganey PE, Luyendyk JP, Maddox JF, Roth RA: Adverse hepatic drug reactions: Inflammatory episodes as consequences and contributor. Chem. Biol. Interact. 150(1): 35-51, 2004.
Luyendyk JP, Maddox JF, Green CD, Ganey PE, Roth RA: Role of hepatic fibrin in idiosyncrasy-like liver injury from lipopolysaccharide-ranitidine coexposure in rats. Hepatology 40(6): 1342-1351, 2004.
Luyendyk JP, Shaw PJ, Green CD, Maddox JF, Ganey PE, Roth RA. Coagulation-mediated hypoxia and neutrophil-dependent hepatic injury in rats given lipopolysaccharide and ranitidine. J. Pharmacol. Exp. Ther., 314(3):1023-31, 2005.
Maddox JF, Luyendyk JP, Cosma GN, Breau AP, Bible RH, Jr., Harrigan GG, Goodacre R, Ganey PE, Cantor GH, Cockerell GL, Roth RA. Metabonomic Evaluation of Idiosyncrasy-like Liver Injury in Rats Cotreated with Ranitidine and Lipopolysaccharide. Toxicol. Appl. Pharmacol., accepted, July 2005.