Biography

My current research focuses on idiosyncratic liver injury induced by concurrent inflammation and xenobiotic exposure. In many of our models of idiosyncratic drug reactions, the coagulation system is activated leading to hypoxia in the liver. My project focuses on the interactions between tissue hypoxia and inflammatory mediators (released by neutrophils) in the development and progression of hepatocyte death.

Selected Achievements and Awards
Michigan State University Center for Integrative Toxicology Student Travel Award for SOT Annual Meeting, 2006, 2007 and 2008.

Committees and Activities
Society of Toxicology, Regional Chapter Graduate Committee chairperson elect 2008 – 2010
Michigan Society of Toxicology, Student Representative 2007 -2009
Society of Toxicology, Regulatory Affairs and Legislative Assistance Committee, Student Representative 2007 – 2008.

Selected Publications and Abstracts

Sparkenbaugh, E., Shaw, P., Ganey, P., Roth, R., Blomme, E., Dietwig, A., Liguori, M., and J Waring.  Microarray analysis of trovafloxacin-induced gene expression changes in human hepatocytes compared to hepatocytes isolated from rats pre-treated with LPS.  Presented at the Annual Meeting of the Society of Toxicology,March 2008.

Deng, X., Liguori, M., Sparkenbaugh, E., Waring, J., Blomme, E., Ganey, P., and R. Roth.  Gene expression profiles in livers from diclofenac-treated rats reveal intestinal bacteria-dependent and –independent pathways associated with liver injury.  Submitted to the Journal of Pharmacology and Experimental Therapeutics, May 2008.

Sparkenbaugh, E., Atchison, D., Hajela, R., and W. Atchison.   Differential effects of Ca2+ channel alpha1 subunits on methylmercury-induced changes in [Ca2+]I in HEK293 cells.  Presented at the Annual Meeting of the Society of Toxicology, March 2007.