William Jackson, PhD

he/him/his
Professor
Pharmacology & Toxicology

Bio

Dr. Jackson is Professor of Pharmacology and Toxicology at Michigan State University. Received his Ph.D. in Physiology from Michigan State University in 1979 and was a postdoctoral fellow in Dr. Brian Duling’s lab in the Department of physiology at the University of Virginia. He then moved to the Department of Physiology and Endocrinology at the Medical College of Georgia where is rose from the rank of Assistant Professor to Associate Professor. He then moved to the Department of Biological Sciences at Western Michigan University where he rose to the rank of Professor. In 1998 he was named a Distinguished Faculty Scholar WMU’s highest award for his research accomplishments. In 2005 he was recruited back to MSU to start an online Professional Science Masters program in Integrative Pharmacology and is the founding Director of this program. Dr. Jackson’s research focuses on identifying the ion channels expressed by both arteriolar smooth muscle and endothelial cells, how these ion channels function in the regulation of myogenic tone; the mechanisms underlying vasoconstriction and vasodilation; oxygen signaling in the microcirculation. and how aging and disease states such as hypertension and obesity impact the expression and function of ion channels in the microcirculation.

Colleges

• College of Osteopathic Medicine

Education

• M.S. Applied Mathematics, Mathematics, Michigan State University (1978-09-01—1980-08-15)
• Ph.D., Physiology, Michigan State University (1976-08-16—1979-08-15)
• M.S., Physiology, Michigan State University (1974-07-01—1976-08-15)
• B.S., Zoology, Michigan State University (1970-09-01—1974-06-30)

Works

• The conducted vasomotor response and the principles of electrical communication in resistance arteries. Physiological Reviews (2024-01-01)
• 5‐HT7 receptors mediate dilation of rat cremaster muscle arterioles in vivo. Microcirculation (2023)
• Female mice are protected from impaired parenchymal arteriolar TRPV4 function and impaired cognition in hypertension. American Journal of Physiology-Heart and Circulatory Physiology (2023-05-01)
• Genetic ablation of smooth muscle K_IR2.1 is inconsequential to the function of mouse cerebral arteries. Journal of Cerebral Blood Flow & Metabolism (2022)
• Poorly controlled hypertension is associated with increased coronary myogenic tone in patients undergoing cardiac surgery with cardiopulmonary bypass. The Journal of Thoracic and Cardiovascular Surgery (2022)
• The heat is on! TRPV1 channels and resistance artery myogenic tone. The Journal of Physiology (2022)
• Endothelial Ion Channels and Cell-Cell Communication in the Microcirculation. Frontiers in Physiology (2022-02-08)
• Something's fishy: cardiovascular ATP‐sensitive K+ channels in zebrafish. The Journal of Physiology (2022)
• Calcium-Dependent Ion Channels and the Regulation of Arteriolar Myogenic Tone. Frontiers in Physiology (2021-11-08)
• Myogenic Tone in Peripheral Resistance Arteries and Arterioles: The Pressure Is On!. Frontiers in Physiology (2021-07-22)
• Capillary Inward-Rectifying K+ Crippled in a Mouse Model of Alzheimer’s Disease: Phosphatidylinositol 4,5-Bisphosphate to the Rescue!. Function (2021-03-22)
• Another Piece of the Puzzle. Circulation Research (2021-03-19)
• Soluble epoxide hydrolase inhibition improves cognitive function and parenchymal artery dilation in a hypertensive model of chronic cerebral hypoperfusion. Microcirculation (2021)
• Introduction to ion channels and calcium signaling in the microcirculation. Current Topics in Membranes (2020)
• Ion channels and the regulation of myogenic tone in peripheral arterioles. Current Topics in Membranes (2020)
• Transient receptor potential vanilloid 4 channels are important regulators of parenchymal arteriole dilation and cognitive function. Microcirculation (2019)
• Mineralocorticoid receptor antagonism improves parenchymal arteriole dilation via a TRPV4-dependent mechanism and prevents cognitive dysfunction in hypertension. American Journal of Physiology-Heart and Circulatory Physiology (2018-11-01)
• Voltage-gated Ca2+ channel activity modulates smooth muscle cell calcium waves in hamster cremaster arterioles. American Journal of Physiology-Heart and Circulatory Physiology (2018-10-01)
• KV channels and the regulation of vascular smooth muscle tone. Microcirculation (2018)
• K-V channels and the regulation of vascular smooth muscle tone. Microcirculation (2018)
• Carotid artery stenosis in hypertensive rats impairs dilatory pathways in parenchymal arterioles. American Journal of Physiology-Heart and Circulatory Physiology (2018)
• T‐type voltage‐gated Ca2+ channels do not contribute to the negative feedback regulation of myogenic tone in murine superior epigastric arteries. Pharmacology Research & Perspectives (2017)
• T-type voltage-gated Ca2+ channels do not contribute to the negative feedback regulation of myogenic tone in murine superior epigastric arteries. Pharmacology Research & Perspectives (2017)
• Boosting the signal: Endothelial inward rectifier K+ channels. Microcirculation (2017)
• Endothelial Mineralocorticoid Receptor Mediates Parenchymal Arteriole and Posterior Cerebral Artery Remodeling During Angiotensin II-Induced Hypertension. Hypertension (2017)
• Increased amplitude of inward rectifier K+ currents with advanced age in smooth muscle cells of murine superior epigastric arteries. American Journal of Physiology-Heart and Circulatory Physiology (2017)
• Potassium Channels in Regulation of Vascular Smooth Muscle Contraction and Growth. Advances in pharmacology (San Diego, Calif.) (2017)
• Regional heterogeneity in the mechanisms of myogenic tone in hamster arterioles. American Journal of Physiology-Heart and Circulatory Physiology (2017)
• Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles. Comprehensive Physiology (2017)
• Aging is associated with changes to the biomechanical properties of the posterior cerebral artery and parenchymal arterioles. American Journal of Physiology-Heart and Circulatory Physiology (2016)
• Arteriolar oxygen reactivity: where is the sensor and what is the mechanism of action?. Journal of Physiology-London (2016)
• Bilateral common carotid artery stenosis in normotensive rats impairs endothelium-dependent dilation of parenchymal arterioles. American Journal of Physiology-Heart and Circulatory Physiology (2016)
• DOCA-salt hypertension impairs artery function in rat middle cerebral artery and parenchymal arterioles. Microcirculation (2016)
• Regional heterogeneity in the reactivity of equine small pulmonary blood vessels. Journal of Applied Physiology (2016)
• Aging Alters Vascular Stiffness in the Posterior Cerebral Artery in C57bl/6 Mice. Stroke (2015)
• Divergent signaling mechanisms for venous versus arterial contraction as revealed by endothelin-1. Journal of Vascular Surgery (2015)
• Exercise-induced pulmonary haemorrhage: A progressive disease affecting performance?. Equine Veterinary Journal (2015)
• Organic cation transporter 3 contributes to norepinephrine uptake into perivascular adipose tissue. American Journal of Physiology-Heart and Circulatory Physiology (2015)
• Regulation of myogenic tone and structure of parenchymal arterioles by hypertension and the mineralocorticoid receptor. American Journal of Physiology-Heart and Circulatory Physiology (2015)
• Aging increases capacitance and spontaneous transient outward current amplitude of smooth muscle cells from murine superior epigastric arteries. American Journal of Physiology-Heart and Circulatory Physiology (2014)
• Lung region and racing affect mechanical properties of equine pulmonary microvasculature. Journal of Applied Physiology (2014)
• Perivascular adipose tissue contains functional catecholamines. Pharmacology research & perspectives (2014)
• Ryanodine receptors are uncoupled from contraction in rat vena cava. Cell Calcium (2013)
• Function and expression of ryanodine receptors and inositol 1,4,5-trisphosphate receptors in smooth muscle cells of murine feed arteries and arterioles. Journal of Physiology-London (2012)
• Reverse-mode Na+/Ca2+ exchange is an important mediator of venous contraction. Pharmacological Research (2012)
• Altered expression and function of ryanodine receptors and FKBP12.6 after subarachnoid hemorrhage: more than meets the eye. Journal of Cerebral Blood Flow and Metabolism (2011)
• Heterogeneous function of ryanodine receptors, but not IP3 receptors, in hamster cremaster muscle feed arteries and arterioles. American Journal of Physiology-Heart and Circulatory Physiology (2011)
• Quick Change Artist Endothelium-Derived Relaxing Factor in Resistance Arteries. Hypertension (2011)
• Standing out in a crowd: knockout of ApoE increases the potency of endothelium-dependent vasodilators in mesenteric arteries. Cardiovascular Research (2011)
• Temperature effects on morphological integrity and Ca2+ signaling in freshly isolated murine feed artery endothelial cell tubes. American Journal of Physiology-Heart and Circulatory Physiology (2011)
• KV1.3 A New Therapeutic Target to Control Vascular Smooth Muscle Cell Proliferation. Arteriosclerosis Thrombosis and Vascular Biology (2010)
• Regional heterogeneity of alpha-adrenoreceptor subtypes in arteriolar networks of mouse skeletal muscle. Journal of Physiology-London (2010)
• Connexin isoform expression in smooth muscle cells and endothelial cells of hamster cheek pouch arterioles and retractor feed arteries. Microcirculation (2008)
• Smooth muscle alpha(1D)-adrenoceptors mediate phenylephrine-induced vasoconstriction and increases in endothelial cell Ca(2+) in hamster cremaster arterioles. British Journal of Pharmacology (2008)
• Vanishing act - Protein kinase C-dependent internalization of adenosine 5 '-triphosphate-sensitive K+ channels. Hypertension (2008)
• Activation of potassium channels by tempol in arterial smooth muscle cells from normotensive and deoxycorticosterone acetate-salt hypertensive rats. Hypertension (2006)
• Arteriolar smooth muscle Ca2+ dynamics during blood flow control in hamster cheek pouch. Journal of Applied Physiology (2006)
• Inward rectifying potassium channels facilitate cell-to-cell communication in hamster retractor muscle feed arteries. American Journal of Physiology-Heart and Circulatory Physiology (2006)
• Silent inward rectifier K+ channels in hypercholesterolemia. Circulation Research (2006)
• Vascular smooth muscle store-operated Ca2+ channels: what a TRP!. American Journal of Physiology-Heart and Circulatory Physiology (2006)
• Membrane hyperpolarization is not required. for sustained muscarinic agonist-induced increases in intracellular Ca2+ in arteriolar endothelial cells. Microcirculation (2005)
• Potassium channels and proliferation of vascular smooth muscle cells. Circulation Research (2005)
• Potassium channels in the peripheral microcirculation. Microcirculation (2005)
• K+-induced dilation of hamster cremasteric arterioles involves both the Na+/K+-ATPase and inward-rectifier K+ channels. Microcirculation (2004)
• Hypoxia inhibits contraction but not calcium channel currents or changes in intracellular calcium in arteriolar muscle cells. Microcirculation (2003)
• CB1 receptor antagonist SR141716A inhibits Ca2+-induced relaxation in CB1 receptor-deficient mice. Hypertension (2002)
• Inhibition of Ca2+-induced relaxation by oxidized tungsten wires and paratungstate. Journal of Pharmacology and Experimental Therapeutics (2001)
• Potassium channels in the circulation of skeletal muscle. Potassium Channels in Cardiovascular Biology (2001)
• Hypoxia does not activate ATP-sensitive K+ channels in arteriolar muscle cells. Microcirculation (2000)
• Ion channels and vascular tone. Hypertension (2000)
• Cytochrome P-450 omega-hydroxylase senses O-2 in hamster muscle, but not cheek pouch epithelium, microcirculation. American Journal of Physiology-Heart and Circulatory Physiology (1999)
• Characterization and function of Ca2+-activated K+ channels in arteriolar muscle cells. American Journal of Physiology-Heart and Circulatory Physiology (1998)
• Intracellular acidosis differentially regulates K-V channels in coronary and pulmonary vascular muscle. American Journal of Physiology-Heart and Circulatory Physiology (1998)
• Oxygen induces electromechanical coupling in arteriolar smooth muscle cells: a role for L-type Ca2+ channels. American Journal of Physiology-Heart and Circulatory Physiology (1998)
• Potassium channels and regulation of the microcirculation. Microcirculation (1998)
• Enzymatic isolation and characterization of single vascular smooth muscle cells from cremasteric arterioles. Microcirculation-London (1997)
• Rp diastereomeric analogs of cAMP inhibit both cAMP- and cGMP-induced dilation of hamster mesenteric small arteries. Pharmacology (1996)
• SELECTIVE IN-VIVO ANTAGONISM OF PINACIDIL-INDUCED HYPOTENSION BY THE GUANIDINE U37883A IN ANESTHETIZED RATS. Pharmacology (1994)
• ARTERIOLAR TONE IS DETERMINED BY ACTIVITY OF ATP-SENSITIVE POTASSIUM CHANNELS. American Journal of Physiology (1993)
• Arteriolar tone is determined by activity of ATP-sensitive potassium channels. American Journal of Physiology (1993)
• PROSTACYCLIN-INDUCED VASODILATION IN RABBIT HEART IS MEDIATED BY ATP-SENSITIVE POTASSIUM CHANNELS. American Journal of Physiology (1993)
• REGIONAL DIFFERENCES IN MECHANISM OF ACTION OF OXYGEN ON HAMSTER ARTERIOLES. American Journal of Physiology (1993)
• ARTERIOLAR VASOMOTION A ROLE FOR NITRIC OXIDE IN THE MICROCIRCULATION?. Mulvany, M. J., Et Al. (Ed.). International Congress Series, 974. Resistance Arteries: Structure and Function; Third International Symposium on Resistance Arteries, Rebild, Denmark, May 21-25, 1991. Xv+417p. Elsevier Science Publishers B.v.: Amsterdam, Netherlands; (Dist. in the USA and Canada By Elsevier Science Publishing Co., Inc.: New York, New York, USA). Illus (1991)
• ELEVATED GUANOSINE 3'-5'-CYCLIC MONOPHOSPHATE MEDIATES THE DEPRESSION OF NITROVASODILATOR REACTIVITY IN ENDOTHELIUM-INTACT BLOOD-VESSELS. Naunyn-Schmiedebergs Archives of Pharmacology (1991)
• MODULATION OF VASCULAR REACTIVITY TO SEROTONIN IN THE DOG LUNG. Journal of Applied Physiology (1991)
• NITRIC-OXIDE DOES NOT MEDIATE ARTERIOLAR OXYGEN REACTIVITY. Microcirculation Endothelium and Lymphatics (1991)
• ARTERIOLAR OXYGEN REACTIVITY IS INHIBITED BY LEUKOTRIENE ANTAGONISTS. American Journal of Physiology (1989)
• LIPOXYGENASE INHIBITORS BLOCK O-2 RESPONSES OF HAMSTER-CHEEK POUCH ARTERIOLES. American Journal of Physiology (1988)
• OSCILLATIONS IN ACTIVE TENSION IN HAMSTER AORTAS - ROLE OF THE ENDOTHELIUM. Blood Vessels (1988)
• ARTERIOLAR OXYGEN REACTIVITY - WHERE IS THE SENSOR. American Journal of Physiology (1987)
• PROSTAGLANDINS DO NOT MEDIATE ARTERIOLAR OXYGEN REACTIVITY. American Journal of Physiology (1986)
• IS THE VESSEL WALL BOTH SENSOR AND EFFECTOR IN LOCAL-CONTROL OF BLOOD-FLOW. International Journal of Microcirculation-Clinical and Experimental (1984)
• THE OXYGEN SENSITIVITY OF HAMSTER-CHEEK POUCH ARTERIOLES - INVITRO AND INSITU STUDIES. Circulation Research (1983)
• A COMPARISON OF MICROVASCULAR ESTIMATES OF CAPILLARY BLOOD-FLOW WITH DIRECT MEASUREMENTS OF TOTAL STRIATED-MUSCLE FLOW. International Journal of Microcirculation-Clinical and Experimental (1982)
• FACTORS AFFECTING (H2O)-H-3 TRANSFER CAPACITY OF ISOLATED PERFUSED TROUT GILLS. American Journal of Physiology (1981)
• EFFECT OF ACUTE ACID STRESS ON ISOLATED PERFUSED GILLS OF RAINBOW-TROUT. Comparative Biochemistry and Physiology C-Pharmacology Toxicology & Endocrinology (1980)
• EFFECT OF A DETERGENT ON FLUX OF TRITIATED-WATER INTO ISOLATED PERFUSED GILLS OF RAINBOW-TROUT. Comparative Biochemistry and Physiology C-Pharmacology Toxicology & Endocrinology (1977)

Employment

• Professor, Michigan State University (2005-05-01)
• Professor, Western Michigan University (1989-08-15—2005-04-30)
• Associate Professor, Augusta University Medical College of Georgia (1983-08-01—1989-08-14)