Hakan Orer, Visiting Associate Professor
1986 M.D., Hacettepe University, Faculty of Medicine, Ankara, Turkey
1988-1991 Research Associate, INSERM U288 Pitié-Salpêtrière Faculty of Medicine, Paris, France.
1992 Ph.D., Pharmacology, Hacettepe University, Health Sciences Institute, Ankara, Turkey.
1993-1995 Research Associate, Department of Pharmacology & Toxicology, Michigan State University
1995-1997 Assistant Professor, Dept. of Pharmacology, Faculty of Medicine, Hacettepe Univ., Ankara, Turkey.
1997-2002 Associate Professor, Dept. of Pharmacology, Faculty of Medicine, Hacettepe Univ., Ankara, Turkey.
2002-2003 Visiting Associate Professor, Department of Pharmacology & Toxicology, Michigan State University,
2003-present, Professor, Dept. of Pharmacology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
2005-present, Visiting Professor, Michigan State University
Blood pressure, like other vital variables, e.g. respiration, is under phasic and tonic control of the central structures located in the brain stem. Despite the wealth of information accumulated over more than a century, wiring and functioning of the brain stem structures involved in this control have not yet been fully understood. Communication and information coding in the brain stem, as well as the generation of sympathetic tone to maintain an adequate blood supply to different organs and under different circumstances constitute the main scope of my research which benefits from a long term collaboration with Professors S. M. Barman and G. L. Gebber.
Selected Achievements Since 2001
2004-present Treasurer & Council Member, Turkish Pharmacological Society.
2003-present Director, Graduate Studies Institute for Allied Health Sciences (Institute of Health Sciences), Hacettepe University, Ankara, Turkey.
2001-present Head, Surgical Research and Laboratory Animals Breeding Unit, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
2001-2004 Member, Central Ethics Committee for Drug Investigations. Ministry of Health, Ankara, Turkey.
Awards
1998 Turkish Scientific and Technique Research Council (TUBITAK), Young Scientist Award
1987 Sandoz (Novartis) Medicine Award
Selected Publications Since 2001
Barman SM, Orer HS, and Gebber GL. Differential effects of an NMDA and a non-NMDA receptor antagonist on medullary lateral tegmental field neurons. In: Am J Physiol Regul Integr Comp Physiol, 2002, p. R100-113.
Barman SM, Orer HS, and Gebber GL. The role of the medullary lateral tegmental field in the generation and baroreceptor reflex control of sympathetic nerve discharge in the cat. In: Ann N Y Acad Sci, 2001, p. 270-285.
Fadel PJ, Orer HS, Barman SM, Vongpatanasin W, Victor RG, and Gebber GL. Fractal properties of human muscle sympathetic nerve activity. In: Am J Physiol Heart Circ Physiol, 2004, p. H1076-1087.
Firat MM, Gelebek V, Orer HS, Belen D, Firat AK, and Balkanci F. Selective intraarterial nimodipine treatment in an experimental subarachnoid hemorrhage model. Am J Neuroradiol 26: 1357-1362, 2005.
Orer HS, Barman SM, and Gebber GL. Effects on sympathetic activity of 8-OHDPAT and clonidine in cat medullary lateral tegmental field. In: Am J Physiol Heart Circ Physiol, 2001, p. H613-622.
Orer HS, Das M, Barman SM, and Gebber GL. Fractal activity generated independently by medullary sympathetic premotor and preganglionic sympathetic neurons. In: J Neurophysiol, 2003, p. 47-54.
Orer HS, Gebber GL, Phillips SW, and Barman SM. Role of the medullary lateral tegmental field in reflex-mediated sympathoexcitation in cats. In: Am J Physiol Regul Integr Comp Physiol, 2004, p. R451-464.
Otcu S, Durakogugil M, Orer HS, and Tanyel FC. Contralateral genitofemoral sympathetic nerve discharge increases following ipsilateral testicular torsion. Urol Res 30: 324-328, 2002.
Phillips SW, Orer HS, Fadel PJ, Barman SM, and Gebber GL. Fractal heart rate variability (HRV) and muscle sympathetic nerve discharge (SND) in awake humans and Dial-urethane anesthetized cats. Faseb J 18: A1080-A1080, 2004.
Tombakoglu M, Durakoglugil M, Kale G, Orer HS, Bulun A, and Anlar B. Transient intrauterine hypotension causes apoptosis in fetal rat brain and affects learning. In: Pediatr Res, 2003, p. 977-982.