Neera Tewari-Singh, PhD

Associate Professor
Pharmacology & Toxicology

tewarisi@msu.edu

(517) 884-0252

B307 Life Sciences

Research

Lab Staff

Steve Lundback

Mentees

Colleges

College of Osteopathic Medicine

Programs

Sections

PHM 816 Integrative Toxicology: Mechanisms, Pathology and Regulation (in-person) - Fall Odd Years

Funding

Phosgene Oxime Cutaneous Toxicity and Mechanisms to Identify Therapeutic Targets, National Institute of Arthritis and Musculoskeletal and Skin Diseases (2017-09-21—2020-08-31)
Targeted Therapeutic Approaches to Counteract Toxicity from Phosgene Oxime Skin Exposure, National Institute of Arthritis and Musculoskeletal and Skin Diseases (2019-09-10—2022-08-31)
Treatment strategies for ocular toxicity from chloropicrin, National Eye Institute (2021-09-01—2024-08-31)
Understanding Mustard Vesicants Distribution and Toxicity in the Eye Using In Vivo and In Silico Models, National Eye Institute (2023-09-01—2026-08-31)

Works

Dermal Exposure to Vesicating Nettle Agent Phosgene Oxime: Clinically Relevant Biomarkers and Skin Injury Progression in Murine Models. The Journal of pharmacology and experimental therapeutics (2024)
Dexamethasone targets actin cytoskeleton signaling and inflammatory mediators to reverse sulfur mustard-induced toxicity in rabbit corneas. Toxicology and applied pharmacology (2024)
Establishing a Dexamethasone Treatment Regimen To Alleviate Sulfur Mustard-Induced Corneal Injuries in a Rabbit Model. The Journal of pharmacology and experimental therapeutics (2024)
Nitrogen Mustard-Induced Ex Vivo Human Cornea Injury Model and Therapeutic Intervention by Dexamethasone. The Journal of pharmacology and experimental therapeutics (2024)
Metabolomics for identifying pathways involved in vesicating agent lewisite-induced corneal injury. Experimental eye research (2023)
Ocular injury progression and cornea histopathology from chloropicrin vapor exposure: Relevant clinical biomarkers in mice. Experimental Eye Research (2023)
A review of chemical warfare agents linked to respiratory and neurological effects experienced in Gulf War Illness. Inhalation toxicology (2022)
Effect of dexamethasone treatment at variable therapeutic windows in reversing nitrogen mustard-induced corneal injuries in rabbit ocular in vivo model. Toxicology and applied pharmacology (2022)
Mast Cells Promote Nitrogen Mustard-Mediated Toxicity in the Lung Associated With Proinflammatory Cytokine and Bioactive Lipid Mediator Production. Toxicological sciences : an official journal of the Society of Toxicology (2021)
Pathophysiology and inflammatory biomarkers of sulfur mustard-induced corneal injury in rabbits. PloS one (2021)
Effect of supersaturated oxygen emulsion treatment on chloropicrin-induced chemical injury in ex vivo rabbit cornea. Toxicology letters (2021)
Special issue: emerging chemical terrorism threats. Toxicology mechanisms and methods (2021)
Phosgene oxime: a highly toxic urticant and emerging chemical threat. Toxicology mechanisms and methods (2020)
Toxic consequences and oxidative protein carbonylation from chloropicrin exposure in human corneal epithelial cells. Toxicology Letters (2020)
A Supersaturated Oxygen Emulsion for the Topical Treatment of Ocular Trauma. Military medicine (2020)
Acute corneal injury in rabbits following nitrogen mustard ocular exposure. Experimental and molecular pathology (2019)
Histopathological and Molecular Changes in the Rabbit Cornea From Arsenical Vesicant Lewisite Exposure. Toxicological sciences : an official journal of the Society of Toxicology (2017)
Efficacy of anti-inflammatory, antibiotic and pleiotropic agents in reversing nitrogen mustard-induced injury in ex vivo cultured rabbit cornea. Toxicology letters (2017)
Phosgene oxime: Injury and associated mechanisms compared to vesicating agents sulfur mustard and lewisite. Toxicology letters (2017)
Cutaneous exposure to vesicant phosgene oxime: Acute effects on the skin and systemic toxicity. Toxicology and applied pharmacology (2017)
Corneal toxicity induced by vesicating agents and effective treatment options. Annals of the New York Academy of Sciences (2016)
Mustard vesicating agent-induced toxicity in the skin tissue and silibinin as a potential countermeasure. Annals of the New York Academy of Sciences (2016)
Clinical progression of ocular injury following arsenical vesicant lewisite exposure. Cutaneous and ocular toxicology (2016)
Nitrogen Mustard-Induced Corneal Injury Involves DNA Damage and Pathways Related to Inflammation, Epithelial-Stromal Separation, and Neovascularization. Cornea (2016)
Nitrogen mustard exposure of murine skin induces DNA damage, oxidative stress and activation of MAPK/Akt-AP1 pathway leading to induction of inflammatory and proteolytic mediators. Toxicology letters (2015)
Flavanone silibinin treatment attenuates nitrogen mustard-induced toxic effects in mouse skin. Toxicology and applied pharmacology (2015)
Topical nitrogen mustard exposure causes systemic toxic effects in mice. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie (2014)
Catalytic antioxidant AEOL 10150 treatment ameliorates sulfur mustard analog 2-chloroethyl ethyl sulfide-associated cutaneous toxic effects. Free radical biology & medicine (2014)
Activation of DNA damage repair pathways in response to nitrogen mustard-induced DNA damage and toxicity in skin keratinocytes. Mutation research (2014)
Myeloperoxidase deficiency attenuates nitrogen mustard-induced skin injuries. Toxicology (2014)
Cutaneous injury-related structural changes and their progression following topical nitrogen mustard exposure in hairless and haired mice. PloS one (2014)
Histopathological and immunohistochemical evaluation of nitrogen mustard-induced cutaneous effects in SKH-1 hairless and C57BL/6 mice. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie (2013)
Absence of a p53 allele delays nitrogen mustard-induced early apoptosis and inflammation of murine skin. Toxicology (2013)
Clinically-relevant cutaneous lesions by nitrogen mustard: useful biomarkers of vesicants skin injury in SKH-1 hairless and C57BL/6 mice. PloS one (2013)
Silibinin attenuates sulfur mustard analog-induced skin injury by targeting multiple pathways connecting oxidative stress and inflammation. PloS one (2012)
Silibinin, dexamethasone, and doxycycline as potential therapeutic agents for treating vesicant-inflicted ocular injuries. Toxicology and applied pharmacology (2012)
Mechanisms of sulfur mustard analog 2-chloroethyl ethyl sulfide-induced DNA damage in skin epidermal cells and fibroblasts. Free radical biology & medicine (2011)
Sulfur mustard analog, 2-chloroethyl ethyl sulfide-induced skin injury involves DNA damage and induction of inflammatory mediators, in part via oxidative stress, in SKH-1 hairless mouse skin. Toxicology letters (2011)
2-Chloroethyl ethyl sulfide causes microvesication and inflammation-related histopathological changes in male hairless mouse skin. Toxicology (2011)
Efficacy of glutathione in ameliorating sulfur mustard analog-induced toxicity in cultured skin epidermal cells and in SKH-1 mouse skin in vivo. The Journal of pharmacology and experimental therapeutics (2010)
Biological and molecular mechanisms of sulfur mustard analogue-induced toxicity in JB6 and HaCaT cells: possible role of ataxia telangiectasia-mutated/ataxia telangiectasia-Rad3-related cell cycle checkpoint pathway. Chemical research in toxicology (2010)
Sulfur mustard analog induces oxidative stress and activates signaling cascades in the skin of SKH-1 hairless mice. Free radical biology & medicine (2009)
Engineering key components in a synthetic eukaryotic signal transduction pathway. Molecular systems biology (2009)
Inflammatory biomarkers of sulfur mustard analog 2-chloroethyl ethyl sulfide-induced skin injury in SKH-1 hairless mice. Toxicological sciences : an official journal of the Society of Toxicology (2008)
Tumor necrosis factor-alpha induces endothelial dysfunction in Lepr(db) mice. Circulation (2007)
A synthetic de-greening gene circuit provides a reporting system that is remotely detectable and has a re-set capacity. Plant biotechnology journal (2006)
Use of a herbicide or lysine plus threonine for non-antibiotic selection of transgenic chickpea. Plant cell reports (2004)

Employment

Associate Professor, Michigan State University (2023-07-01)
Assistant Professor, Michigan State University (2019-01-01—2023-06-30)
Assistant Research Professor, University of Colorado Denver (2014-01-01—2018-12-31)